Recent publication from the group entitled Asymmetric Hydrosilylation of Ketones Catalyzed by Zinc Acetate with Hindered Pybox Ligands has been published in Adv. Synth. Catal. (link to page)

Recent publication from the group entitled Amine-Catalyzed Direct Aldol Reactions of Hydroxy- and Dihydroxyacetone: Biomimetic Synthesis of Carbohydrates has been published in J. Org. Chem. (link to page)


Publication entitled Asymmetric syn-Aldol Reaction of Hydroxyketones via Tertiary Amine Catalysts has been published in Eur. J. Org. Chem. (link to page)

Communication entitled General Switch in Regioselectivity in the Mukaiyama Aldol Recation of Silyloxyfuran with aldehydes in Aqueous Solvents has been published in Chem. Commun. (link to page)




Catalytic Asymmetric Aldol Reaction in Aqueous Media -
- a 5 Year Update

Asymmetric reactions in water and in aqueous solutions have become an area of fast growing interest recently. Although for a long time neglected as a medium for organic reactions, water has attracted attention as the most widely distributed solvent in the world. Indeed, water is the solvent used by nature for biological chemistry including aldol reactions being essential for glycolysis, gluconeogenesis and related processes. Consequently, artificial catalysts designed and used for aldol reactions in water can be promising for the synthesis of enantiopure molecules and are also important for the understanding of complex chemistry of life.

This tutorial review summarizes recent developments in the area of aqueous asymmetric aldol reactions highlighting two fundamental directions – development of water compatible chiral Lewis acids and amine-based organocatalysts.

Chem. Soc. Rev. 2014 43 577-587 (link to page)



The key role of carbohydrates in biological processes and their visible existence in our everyday life have stimulated the interest of leading research groups on the smart and simple synthesis of common and rare sugar molecules. Now, more than 120 years after Fischer's first synthesis of (D)-glucose (1890), we are witnessing important development in this field of total synthesis. Using modern methods of direct activation of carbonyl compounds chemists can prepare sugars in an elegant and efficient way similar to that of Nature. Thistutorial review presents recent impressive progress in the area of de novo synthesis of carbohydrates by using organocatalytic direct aldol reaction as a key step.

Chem. Soc. Rev. 2012 41 587 (link to page)





Asymmetric Aldol Reaction in Water


Wet and wild: Water is a powerful force in nature, as well as a promising medium for asymmetric reactions. As catalysts, natural amino acids are ideal candidates. Our Minireview in Angewandte Chemie summarizes recent advances in asymmetric catalysis in water, with amino acids and their derivatives as effective catalysts or essential components.

Angew. Chem. Int. Ed. 2009 48 4288 (link to page)

Chem. Soc. Rev. 2008 37 1502 (link to page)


ES by Zdzislaw Beksinski 1985, oil, 92 cm×90 cm

reproduced with permission from Piotr Dmochowski